We've posted the manuscript on the public arXiv.org server. You can download the full pdf, including all the supplementary data, at http://arxiv.org/abs/1201.6643.
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Are there any rules against posting the editorial process (editor comments, anonymous reviews, etc) here?
ReplyDeleteNot as far as I know, so I'll post them once we receive them.
DeleteI'm soliciting comments from others in a separate post.
It's available now: arXiv:1201.6643 [q-bio]. The arXiv usually updates just after 8 PM Eastern time the evening before the nominal date of the paper. Their clocks are on GMT or something.
ReplyDeleteAs I understand it, Figure 1A has error bars which represent the standard deviation of ion counts for independent purifications of the same DNA sample, characterizing the variance across purifications.
ReplyDeleteWhy use the standard deviation in this case where your sample size=2? Using the two actual values would make more sense to me (estimating the distribution in this case obfuscates the underlying data, as you've irreversibly "reduced" two observed values to two statistical estimates). I think it makes more sense to show the actual observations, or do (at least) three experiments...
Sorry, that should be Supplementary Figure 1.
DeleteFWIW to make sure I wasn't making it up (I've seen error bars on small n estimates before), note the line:
"However, if n is very small (for example n = 3), rather than showing error bars and statistics, it is better to simply plot the individual data points."
Error bars in experimental biology
http://jcb.rupress.org/content/177/1/7.full
Or have the error bars indicate the range rather than standard deviation.
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